Amlodipine Mechanism of Action: The movement of calcium ions in the cells of the musculature of the vessels, the heart muscle. Studies have shown that amlodipine binds to the active centres of dihydropyridine and non-dihydropyridine. The processes of contraction of the cardiac muscle and vascular musculature depend on the penetration of extracellular calcium ions into cells through special ionic tubules. Amlodipine selectively inhibits the process of calcium ions entering the cell membrane, which largely affects the smooth muscle of the vessels, rather than the heart muscle. Negative inotropic effects or reduced contractility of the heart muscle may occur, but such effects are not observed in intact animals at therapeutic doses of the drug. The medicine does not affect the amount of calcium in the serum.[hide]Amlodipine Mechanism of Action[/hide]
Amlodipine is a peripheral vasodilator that acts directly on the smooth muscles of the vessels to cause a decrease in peripheral vascular resistance and blood pressure. It is also assumed that the drug, as a calcium channel blocker inhibits the flow of dihydropyridine tubules of the glomerular zone of the adrenal cortex, reducing the production of aldosterone and maintaining a low blood pressure.
[hide]Amlodipine Mechanism of Action[/hide]Amlodipine also acts as a functional sphingomyelinase acid inhibitor. Sphingomyelin is involved in signal transduction and apoptosis.
[hide]Amlodipine Mechanism of Action[/hide]The exact mechanism of easing the symptoms of angina is not known, although there are some assumptions. with stable angina, amlodipine reduces the overall peripheral resistance and index of the product of frequency, hence reduces the need for myocardium in oxygen. Amlodipine blocks spasm of the coronary arteries and restores blood flow in the coronary arteries and arterioles in response to calcium, potassium, adrenaline, serotonin. Inhibition of coronary spasm shows the effectiveness of the drug in spontaneous angina.[hide]Amlodipine Mechanism of Action[/hide]