Atorvastatin Tablets 10, 20, 40, 80 Mg Dosing and Administration

Dosing and Administration

Inside. Take at any time of the day, regardless of food intake. Before starting treatment, the drug should try to achieve control of hypercholesterolemia with diet, exercise and weight loss in obese patients, as well as therapy for the underlying disease. When appointing the drug, the patient should recommend a standard hypocholesterolemic diet, which he must adhere to throughout the period of therapy.
The dose of the drug varies from 10 mg to 80 mg once a day and is titrated taking into account the initial concentration of LDL-C, the purpose of therapy and the individual effect on the therapy. The maximum daily dose of the drug for a single dose is 80 mg.
At the beginning of treatment and / or during an increase in the dose of the drug, it is necessary to monitor the concentration of lipids in the blood plasma every 2-4 weeks and adjust the dose accordingly.
Primary hypercholesterolemia and combined (mixed) hyperlipidemia
For the majority of patients – 10 mg once a day; The therapeutic effect is manifested during 2 weeks of therapy and usually reaches a maximum within 4 weeks. With prolonged treatment, the effect is preserved.
Homozygous familial hypercholesterolemia
In most cases, appoint 80 mg once a day (lowering the concentration of LDL-C in 18-45%).
Lack of liver function
If liver function is insufficient, the dose of the drug should be reduced, with the regular monitoring of the activity of “liver” transaminases: aspartate aminotransferase (AST) and alanine aminotransferase (ALT).
Inadequate kidney function
Impairment of renal function does not affect the concentration of atorvastatin in the blood plasma or the degree of decrease in the concentration of LDL-C during drug therapy, so dose adjustment is not required.
Elderly patients
No differences in the efficacy, safety or therapeutic effect of the drug in elderly patients have been found in comparison with the general population and no dose adjustment is required (see the section “Pharmacokinetics”).
Use in combination with other medicines. If a simultaneous application with cyclosporine is required, the dose of the drug should not exceed 10 mg per day (see section “Special instructions”). Caution should be exercised and the lowest effective dose of atorvastatin should be used when used simultaneously with HIV protease inhibitors, hepatitis C inhibitors, clarithromycin and itraconazole.

Form of issue

Tablets 10 mg, 20 mg, 40 mg and 80 mg. together with the instruction for use is placed in a cardboard box.
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