A drug from alpha and beta-adrenoblockers, which has antihypertensive, vasodilating, antianginal and antioxidant effects.[hide]Carvedilol Mechanism of Action[/hide]
Mechanism of action
Absorbed into the blood through the digestive organs, Carvedilol penetrates into the alpha-1 and beta-adrenoreceptors of the vessels, blocking them. First of all, in response to this, there is an expansion of the vessels and a decrease in pre- and post-loading on the cardiac muscle. This leads to lower blood pressure, better oxygenation of tissues, reduction of pain in the heart (caused by spasms of vessels feeding the myocardium).[hide]Carvedilol Mechanism of Action[/hide]
Also, drugs with carvedilol restore the ability of the heart to contract, improving the emptying of all the chambers of the heart, preventing stagnation and development of thrombosis. This drug increases the resistance to physical exertion, reduces the overall peripheral vascular resistance and slightly reduces the heart rate.
[hide]Carvedilol Mechanism of Action[/hide]In this case, this drug slightly affects fat metabolism, is involved in the restoration of the structure of membranes (shells) of vascular cells, reduces the blood levels of low-density lipoproteins (“bad” cholesterol).
You can replace the medicine with the same or different composition, but with similar therapeutic properties. The analogues of Carvedilol are:
- Alotendin – hypotensive tablets based on amlodipine, bisoprolol;
- Atram – antioxidant tablets containing carvedilol;
- Carvidex – tablets from the group of beta adrenoblockers based on carvedilol;
- Coriol – antianginal tablets containing carvedilol;
- Dilatrend – vasodilating tablets based on carvedilol.[hide]Carvedilol Mechanism of Action[/hide]
If the maximum daily dose of Carvedilol is exceeded, there may be a marked decrease in pressure, arrhythmia, low heart rate, respiratory failure, cardiac or left ventricular failure. This can result in a cardiac arrest. When signs of overdose show it is necessary to wash the stomach, introduce adrenoreceptor agonists.[hide]Carvedilol Mechanism of Action[/hide]
The drug is used with caution in chronic bronchitis, bronchospastic syndrome, Prinzmetal angina, pheochromocytoma, psoriasis, atrioventricular blockade, diabetes mellitus, hypoglycemia, myasthenia gravis, depression, renal insufficiency. Contraindications are:[hide]Carvedilol Mechanism of Action[/hide]
- bronchial asthma;
- syndrome of a weakness of the sinus node, pronounced bradycardia;
- cardiogenic shock;
- Decompensated heart failure with an installed pacemaker;
- hypersensitivity to components;
- pregnancy, lactation;
- lactose intolerance, lactase deficiency, impaired absorption of galactose-glucose;
- liver failure.
[hide]Carvedilol Mechanism of Action <iframe src=”https://www.youtube.com/embed/LqmBw4aIht8″ frameborder=”0″ allow=”autoplay; encrypted-media” allowfullscreen>[/hide]