Metoprolol for the treatment of the heart

The antianginal effect of metoprolol can be achieved by reducing the need for myocardium in the production of oxygen molecules because of the reduction in the frequency of cardiac contractions. Due to the use of the drug, the sensitivity of the myocardium to the action of innervation decreases, the number of attacks of angina decreases physical load increases. Arterial pressure drops fifteen minutes after taking Metoprolol and continues for the next six hours. Diastolic blood pressure decreases significantly more slowly. A stable decrease is established only a few weeks after the regular use of metoprolol.

The antiarrhythmic effect can be achieved by eliminating the arrhythmogenic factors, which include:

  • Tachycardia;
  • High activity of the nervous system;
  • Increase of cAMP content;
  • Arterial hypertension.

Antiarrhythmic effects are also expressed in a decrease in the rate of spontaneous excitation, which can prevent the onset of a migraine. If you take the drug Metoprolol in an average dosage, then the effect on the organs is less pronounced. Metoprolol is almost immediately absorbed into the gastrointestinal tract in full (95%). The maximum concentration of the drug is reached in the blood two hours after the drug is administered orally. The withdrawal period is 3.5 hours.

The level of bioavailability is equal to fifty percent at the first use of the drug. He grows up to seventy percent with a second admission. If the drug Metoprolol is consumed with food, then the bioavailability is increased by 30%. It also increases with cirrhosis of the liver. The medicine penetrates through the placenta but enters the breast milk only in a small amount.

One of the properties of Metoprolol is the ability to be metabolized in the liver. Metabolites are not characterized by activity. About five percent of the medication is unchanged through the renal system. Treatment of patients suffering from reduced kidney function does not provide for dosage adjustment. If the functioning of the liver is disturbed, the metabolism of the drug also slows down. If the liver function is insufficient, the dosage of the drug is reduced.

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